Elucidation of conditions allowing conversion of penicillin G and other penicillins to deacetoxycephalosporins by resting cells and extracts of Streptomyces clavuligerus NP1

Using resting cells and extracts of Streptomyces clavuligerus NP1, we have been able to convert penicillin G (benzylpenicillin) to deacetoxycephalosporin G. Conversion was achieved by increasing by 45× the concentration of FeSO(4) (1.8 mM) and doubling the concentration of α-ketoglutarate (1.28 mM)...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Cho, Hiroshi, Adrio, José L., Luengo, José M., Wolfe, Saul, Ocran, Simeon, Hintermann, Gilberto, Piret, Jacqueline M., Demain, Arnold L.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21677/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9751702/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.20.11544
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