Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.

Biosynthesis of cephalosporin antibiotics involves an expansion of the five-membered thiazolidine ring of penicillin N to the six-membered dihydrothiazine ring of deacetoxycephalosporin C by a deacetoxycephalosporin C synthetase (DAOCS) enzyme activity. Hydroxylation of deacetoxycephalosporin C to f...

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Bibliografiske detaljer

Udgivet i:	J Bacteriol
Principais autores:	Kovacevic, S, Weigel, B J, Tobin, M B, Ingolia, T D, Miller, J R
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209661/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2644235/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.171.2.754-760.1989
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