Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

Positive supercoils are introduced in cellular DNA in front of and negative supercoils behind tracking polymerases. Since DNA purified from cells is normally under-wound, most studies addressing the relaxation activity of topoisomerase I have utilized negatively supercoiled plasmids. The present rep...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Autori principali: Frøhlich, Rikke From, Veigaard, Christopher, Andersen, Félicie Faucon, McClendon, A. Kathleen, Gentry, Amanda C., Andersen, Anni Hangaard, Osheroff, Neil, Stevnsner, Tinna, Knudsen, Birgitta Ruth
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2007
Soggetti:
Molecular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094083/
https://ncbi.nlm.nih.gov/pubmed/17827209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm669
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi