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Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

Positive supercoils are introduced in cellular DNA in front of and negative supercoils behind tracking polymerases. Since DNA purified from cells is normally under-wound, most studies addressing the relaxation activity of topoisomerase I have utilized negatively supercoiled plasmids. The present rep...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Frøhlich, Rikke From, Veigaard, Christopher, Andersen, Félicie Faucon, McClendon, A. Kathleen, Gentry, Amanda C., Andersen, Anni Hangaard, Osheroff, Neil, Stevnsner, Tinna, Knudsen, Birgitta Ruth
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Oxford University Press 2007
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094083/
https://ncbi.nlm.nih.gov/pubmed/17827209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm669
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