Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

Positive supercoils are introduced in cellular DNA in front of and negative supercoils behind tracking polymerases. Since DNA purified from cells is normally under-wound, most studies addressing the relaxation activity of topoisomerase I have utilized negatively supercoiled plasmids. The present rep...

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Detaylı Bibliyografya
Asıl Yazarlar: Frøhlich, Rikke From, Veigaard, Christopher, Andersen, Félicie Faucon, McClendon, A. Kathleen, Gentry, Amanda C., Andersen, Anni Hangaard, Osheroff, Neil, Stevnsner, Tinna, Knudsen, Birgitta Ruth
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2007
Konular:
Molecular Biology
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094083/
https://ncbi.nlm.nih.gov/pubmed/17827209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm669
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