Tryptophane-205 of human topoisomerase I is essential for camptothecin inhibition of negative but not positive supercoil removal

Positive supercoils are introduced in cellular DNA in front of and negative supercoils behind tracking polymerases. Since DNA purified from cells is normally under-wound, most studies addressing the relaxation activity of topoisomerase I have utilized negatively supercoiled plasmids. The present rep...

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Bibliografski detalji
Glavni autori: Frøhlich, Rikke From, Veigaard, Christopher, Andersen, Félicie Faucon, McClendon, A. Kathleen, Gentry, Amanda C., Andersen, Anni Hangaard, Osheroff, Neil, Stevnsner, Tinna, Knudsen, Birgitta Ruth
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2007
Teme:
Molecular Biology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2094083/
https://ncbi.nlm.nih.gov/pubmed/17827209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm669
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