Mg(2+) mediates interaction between the voltage sensor and cytosolic domain to activate BK channels

The voltage-sensor domain (VSD) of voltage-dependent ion channels and enzymes is critical for cellular responses to membrane potential. The VSD can also be regulated by interaction with intracellular proteins and ligands, but how this occurs is poorly understood. Here, we show that the VSD of the BK...

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Bibliographic Details
Main Authors: Yang, Huanghe, Hu, Lei, Shi, Jingyi, Delaloye, Kelli, Horrigan, Frank T., Cui, Jianmin
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2007
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084332/
https://ncbi.nlm.nih.gov/pubmed/17984060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0705873104
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