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Activation of Slo1 BK channels by Mg(2+) coordinated between the voltage sensor and the RCK1 domains

The voltage sensor domain (VSD) and the ligand sensor (cytoplasmic domain) of BK channels synergistically control channel activities, thereby integrating electrical and chemical signals for cell function. Studies show that intracellular Mg(2+) mediates the interaction between these sensory domains t...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Yang, Huanghe, Shi, Jingyi, Zhang, Guohui, Yang, Junqiu, Delaloye, Kelli, Cui, Jianmin
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2579968/
https://ncbi.nlm.nih.gov/pubmed/18931675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1507
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