Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death

Polyphosphate (polyP) consists of tens to hundreds of phosphates, linked by ATP-like high-energy bonds. Although polyP is present in mammalian mitochondria, its physiological roles there are obscure. Here, we examine the involvement of polyP in mitochondrial energy metabolism and ion transport. We c...

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Hauptverfasser: Abramov, Andrey Y., Fraley, Cresson, Diao, Catherine T., Winkfein, Robert, Colicos, Michael A., Duchen, Michael R., French, Robert J., Pavlov, Evgeny
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2007
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084301/
https://ncbi.nlm.nih.gov/pubmed/17986607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708959104
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