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Cell division modulates prion accumulation in cultured cells

The phenotypic effect of prions on host cells is influenced by the physical properties of the prion strain and its level of accumulation. In mammalian cell cultures, prion accumulation is determined by the interplay between de novo prion formation, catabolism, cell division, and horizontal cell-to-c...

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Autores principales: Ghaemmaghami, Sina, Phuan, Puay-Wah, Perkins, Beth, Ullman, Julie, May, Barnaby C. H., Cohen, Fred E., Prusiner, Stanley B.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2007
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2084281/
https://ncbi.nlm.nih.gov/pubmed/17989223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0708372104
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