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Separate Necdin domains bind ARNT2 and HIF1α and repress transcription
PWS is caused by the loss of expression of a set of maternally imprinted genes including NECDIN (NDN).NDN is expressed in post-mitotic neurons and plays an essential role in PWS as mouse models lacking only the Ndn gene mimic aspects of this disease. Patients haploid for SIM1 develop a PW-like syndr...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2083645/ https://ncbi.nlm.nih.gov/pubmed/17826745 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.08.108 |
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