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The VHL protein recruits a novel KRAB-A domain protein to repress HIF-1α transcriptional activity

The von Hippel-Lindau tumor suppressor (pVHL) is a component of an E3 ubiquitin ligase and targets hypoxia-inducible factor-1α (HIF-1α) for ubiquitylation and degradation under normoxic conditions. pVHL also directly inhibits HIF-1α transactivation by recruiting histone deacetylases. Here, we report...

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Detalhes bibliográficos
Main Authors: Li, Zaibo, Wang, Dakun, Na, Xi, Schoen, Susan R., Messing, Edward M., Wu, Guan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC154465/
https://ncbi.nlm.nih.gov/pubmed/12682018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg173
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