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VHL protein-interacting deubiquitinating enzyme 2 deubiquitinates and stabilizes HIF-1α
Hypoxia-inducible factor (HIF)-1α is a short-lived protein and is ubiquitinated and degraded through the von Hippel–Lindau protein (pVHL)–E3 ubiquitin ligase pathway at normoxia. Deubiquitination, by reversing ubiquitination, has been recognized as an important regulatory step in ubiquitination-rela...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1299287/ https://ncbi.nlm.nih.gov/pubmed/15776016 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.embor.7400377 |
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