Deubiquitination of type 2 iodothyronine deiodinase by von Hippel–Lindau protein–interacting deubiquitinating enzymes regulates thyroid hormone activation

The type 2 iodothyronine deiodinase (D2) is an integral membrane ER-resident selenoenzyme that activates the pro-hormone thyroxine (T4) and supplies most of the 3,5,3′-triiodothyronine (T3) that is essential for brain development. D2 is inactivated by selective conjugation to ubiquitin, a process ac...

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Detalhes bibliográficos
Main Authors: Curcio-Morelli, Cyntia, Zavacki, Ann Marie, Christofollete, Marcelo, Gereben, Balazs, de Freitas, Beatriz C.G., Harney, John W., Li, Zaibo, Wu, Guan, Bianco, Antonio C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC164294/
https://ncbi.nlm.nih.gov/pubmed/12865408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200318348
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