Aggregation of Expanded Polyglutamine Domain in Yeast Leads to Defects in Endocytosis

The role of aggregation of abnormal proteins in cellular toxicity is of general importance for understanding many neurological disorders. Here, using a yeast model, we demonstrate that mutations in many proteins involved in endocytosis and actin function dramatically enhance the toxic effect of poly...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Meriin, Anatoli B., Zhang, Xiaoqian, Miliaras, Nicholas B., Kazantsev, Alex, Chernoff, Yury O., McCaffery, J. Michael, Wendland, Beverly, Sherman, Michael Y.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2003
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC207640/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14560003/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.21.7554-7565.2003
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