Aggregation of Expanded Polyglutamine Domain in Yeast Leads to Defects in Endocytosis

The role of aggregation of abnormal proteins in cellular toxicity is of general importance for understanding many neurological disorders. Here, using a yeast model, we demonstrate that mutations in many proteins involved in endocytosis and actin function dramatically enhance the toxic effect of poly...

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Bibliografske podrobnosti
Main Authors: Meriin, Anatoli B., Zhang, Xiaoqian, Miliaras, Nicholas B., Kazantsev, Alex, Chernoff, Yury O., McCaffery, J. Michael, Wendland, Beverly, Sherman, Michael Y.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2003
Teme:
Cell Growth and Development
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC207640/
https://ncbi.nlm.nih.gov/pubmed/14560003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7554-7565.2003
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