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Aggregation of Expanded Polyglutamine Domain in Yeast Leads to Defects in Endocytosis
The role of aggregation of abnormal proteins in cellular toxicity is of general importance for understanding many neurological disorders. Here, using a yeast model, we demonstrate that mutations in many proteins involved in endocytosis and actin function dramatically enhance the toxic effect of poly...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2003
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC207640/ https://ncbi.nlm.nih.gov/pubmed/14560003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7554-7565.2003 |
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