Aggregation of Expanded Polyglutamine Domain in Yeast Leads to Defects in Endocytosis

The role of aggregation of abnormal proteins in cellular toxicity is of general importance for understanding many neurological disorders. Here, using a yeast model, we demonstrate that mutations in many proteins involved in endocytosis and actin function dramatically enhance the toxic effect of poly...

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Bibliographic Details
Main Authors: Meriin, Anatoli B., Zhang, Xiaoqian, Miliaras, Nicholas B., Kazantsev, Alex, Chernoff, Yury O., McCaffery, J. Michael, Wendland, Beverly, Sherman, Michael Y.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2003
Subjects:
Cell Growth and Development
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC207640/
https://ncbi.nlm.nih.gov/pubmed/14560003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7554-7565.2003
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