Aggregation of Expanded Polyglutamine Domain in Yeast Leads to Defects in Endocytosis

The role of aggregation of abnormal proteins in cellular toxicity is of general importance for understanding many neurological disorders. Here, using a yeast model, we demonstrate that mutations in many proteins involved in endocytosis and actin function dramatically enhance the toxic effect of poly...

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Detalhes bibliográficos
Main Authors: Meriin, Anatoli B., Zhang, Xiaoqian, Miliaras, Nicholas B., Kazantsev, Alex, Chernoff, Yury O., McCaffery, J. Michael, Wendland, Beverly, Sherman, Michael Y.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2003
Assuntos:
Cell Growth and Development
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC207640/
https://ncbi.nlm.nih.gov/pubmed/14560003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7554-7565.2003
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