Role of Nod2 in the Response of Macrophages to Toll-Like Receptor Agonists

Nod2 (CARD15) is a macrophage-specific protein containing two CARD domains, a large nucleotide binding domain and leucine-rich repeats. Human genetic studies have linked mutations in NOD2/CARD15 with Crohn's disease, although the mechanisms involved are unknown. However, Nod2 has been proposed...

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Bibliografiske detaljer
Main Authors: Pauleau, Anne-Laure, Murray, Peter J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2003
Fag:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC207570/
https://ncbi.nlm.nih.gov/pubmed/14560001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.23.21.7531-7539.2003
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