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New 2,6,9-trisubstituted adenines as adenosine receptor antagonists: a preliminary SAR profile

A new series of 2,6,9-trisubstituted adenines (5–14) have been prepared and evaluated in radioligand binding studies for their affinity at the human A(1), A(2A) and A(3) adenosine receptors and in adenylyl cyclase experiments for their potency at the human A(2B) subtype. From this preliminary study...

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Hlavní autoři: Lambertucci, Catia, Cristalli, Gloria, Dal Ben, Diego, Kachare, Dhuldeo D., Bolcato, Chiara, Klotz, Karl-Norbert, Spalluto, Giampiero, Volpini, Rosaria
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Netherlands 2007
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2072915/
https://ncbi.nlm.nih.gov/pubmed/18404447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11302-007-9068-9
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