IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. Here we investigate the roles of the IL-1 receptor 1 (IL-1R1) and the common adaptor for Toll/IL-1R signal transduction, MyD88, in this process using a murine model of acute pulmonary injur...

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Detalhes bibliográficos
Main Authors: Gasse, Pamela, Mary, Caroline, Guenon, Isabelle, Noulin, Nicolas, Charron, Sabine, Schnyder-Candrian, Silvia, Schnyder, Bruno, Akira, Shizuo, Quesniaux, Valérie F.J., Lagente, Vincent, Ryffel, Bernhard, Couillin, Isabelle
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2066195/
https://ncbi.nlm.nih.gov/pubmed/17992263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32285
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