Mycobacterial Phosphatidylinositol Mannosides Negatively Regulate Host Toll-like Receptor 4, MyD88-dependent Proinflammatory Cytokines, and TRIF-dependent Co-stimulatory Molecule Expression

Mycobacterium tuberculosis modulates host immune responses through proteins and complex glycolipids. Here, we report that the glycosylphosphatidylinositol anchor phosphatidyl-myo-inositol hexamannosides PIM(6) or PIM(2) exert potent anti-inflammatory activities. PIM strongly inhibited the Toll-like...

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Detalhes bibliográficos
Main Authors: Doz, Emilie, Rose, Stéphanie, Court, Nathalie, Front, Sophie, Vasseur, Virginie, Charron, Sabine, Gilleron, Martine, Puzo, Germain, Fremaux, Isabelle, Delneste, Yves, Erard, François, Ryffel, Bernhard, Martin, Olivier R., Quesniaux, Valerie F. J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749092/
https://ncbi.nlm.nih.gov/pubmed/19561082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.037846
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