IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice

The molecular mechanisms of acute lung injury resulting in inflammation and fibrosis are not well established. Here we investigate the roles of the IL-1 receptor 1 (IL-1R1) and the common adaptor for Toll/IL-1R signal transduction, MyD88, in this process using a murine model of acute pulmonary injur...

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Détails bibliographiques
Auteurs principaux: Gasse, Pamela, Mary, Caroline, Guenon, Isabelle, Noulin, Nicolas, Charron, Sabine, Schnyder-Candrian, Silvia, Schnyder, Bruno, Akira, Shizuo, Quesniaux, Valérie F.J., Lagente, Vincent, Ryffel, Bernhard, Couillin, Isabelle
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2007
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2066195/
https://ncbi.nlm.nih.gov/pubmed/17992263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32285
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