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Putative Zinc Finger Protein Binding Sites Are Over-Represented in the Boundaries of Methylation-Resistant CpG Islands in the Human Genome

BACKGROUND: Majority of CpG dinucleotides in mammalian genomes tend to undergo DNA methylation, but most CpG islands are resistant to such epigenetic modification. Understanding about mechanisms that may lead to the methylation resistance of CpG islands is still very poor. METHODOLOGY/PRINCIPAL FIND...

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Detalhes bibliográficos
Main Authors: Fan, Shicai, Fang, Fang, Zhang, Xuegong, Zhang, Michael Q.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2065907/
https://ncbi.nlm.nih.gov/pubmed/18030324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001184
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