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OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice forms, whereas further cleavages at protease s...

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Autors principals: Song, Zhiyin, Chen, Hsiuchen, Fiket, Maja, Alexander, Christiane, Chan, David C.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2007
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064540/
https://ncbi.nlm.nih.gov/pubmed/17709429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200704110
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