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The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission
Mitochondrial fusion and structure depend on the dynamin-like GTPase OPA1, whose activity is regulated by proteolytic processing. Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion. Stre...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The Rockefeller University Press
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3998800/ https://ncbi.nlm.nih.gov/pubmed/24616225 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308006 |
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