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The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission

Mitochondrial fusion and structure depend on the dynamin-like GTPase OPA1, whose activity is regulated by proteolytic processing. Constitutive OPA1 cleavage by YME1L and OMA1 at two distinct sites leads to the accumulation of both long and short forms of OPA1 and maintains mitochondrial fusion. Stre...

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Détails bibliographiques
Auteurs principaux: Anand, Ruchika, Wai, Timothy, Baker, Michael J., Kladt, Nikolay, Schauss, Astrid C., Rugarli, Elena, Langer, Thomas
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2014
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3998800/
https://ncbi.nlm.nih.gov/pubmed/24616225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201308006
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