OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L

OPA1, a dynamin-related guanosine triphosphatase mutated in dominant optic atrophy, is required for the fusion of mitochondria. Proteolytic cleavage by the mitochondrial processing peptidase generates long isoforms from eight messenger RNA (mRNA) splice forms, whereas further cleavages at protease s...

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Hlavní autoři: Song, Zhiyin, Chen, Hsiuchen, Fiket, Maja, Alexander, Christiane, Chan, David C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2007
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2064540/
https://ncbi.nlm.nih.gov/pubmed/17709429
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200704110
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