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BLM helicase–dependent and –independent roles of 53BP1 during replication stress–mediated homologous recombination
Mutations in BLM helicase cause Bloom syndrome, characterized by predisposition to all forms of cancer. We demonstrate that BLM, signal transducer 53BP1, and RAD51 interact during stalled replication. Interactions between the three proteins have functional consequences. Lack of 53BP1 decreases the c...
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| Main Authors: | , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2007
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2064412/ https://ncbi.nlm.nih.gov/pubmed/17591918 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200610051 |
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