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Complementation between mouse Mfn1 and Mfn2 protects mitochondrial fusion defects caused by CMT2A disease mutations
Mfn2, an oligomeric mitochondrial protein important for mitochondrial fusion, is mutated in Charcot-Marie-Tooth disease (CMT) type 2A, a peripheral neuropathy characterized by axonal degeneration. In addition to homooligomeric complexes, Mfn2 also associates with Mfn1, but the functional significanc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2007
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063976/ https://ncbi.nlm.nih.gov/pubmed/17296794 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200611080 |
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