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Defective nucleotide-dependent assembly and membrane fusion in Mfn2 CMT2A variants improved by Bax

Mitofusins are members of the dynamin-related protein family of large GTPases that harness the energy from nucleotide hydrolysis to remodel membranes. Mitofusins possess four structural domains, including a GTPase domain, two extended helical bundles (HB1 and HB2), and a transmembrane region. We hav...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Life Sci Alliance
Prif Awduron: Samanas, Nyssa B, Engelhart, Emily A, Hoppins, Suzanne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Life Science Alliance LLC 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7136618/
https://ncbi.nlm.nih.gov/pubmed/32245838
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201900527
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