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Syk-Mediated Translocation of PI3Kδ to the Leading Edge Controls Lamellipodium Formation and Migration of Leukocytes
The non-receptor tyrosine kinase Syk is mainly expressed in the hematopoietic system and plays an essential role in β(2) integrin-mediated leukocyte activation. To elucidate the signaling pathway downstream of Syk during β(2) integrin (CD11/CD18)-mediated migration and extravasation of polymorphonuc...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2063580/ https://ncbi.nlm.nih.gov/pubmed/17987119 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001132 |
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