Syk-Mediated Translocation of PI3Kδ to the Leading Edge Controls Lamellipodium Formation and Migration of Leukocytes

The non-receptor tyrosine kinase Syk is mainly expressed in the hematopoietic system and plays an essential role in β(2) integrin-mediated leukocyte activation. To elucidate the signaling pathway downstream of Syk during β(2) integrin (CD11/CD18)-mediated migration and extravasation of polymorphonuc...

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Detalhes bibliográficos
Main Authors: Schymeinsky, Jürgen, Then, Cornelia, Sindrilaru, Anca, Gerstl, Ronald, Jakus, Zoltán, Tybulewicz, Victor L. J., Scharffetter-Kochanek, Karin, Walzog, Barbara
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2007
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2063580/
https://ncbi.nlm.nih.gov/pubmed/17987119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001132
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