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Cooperative activation of Src family kinases by SH3 and SH2 ligands
Src family nonreceptor tyrosine kinases are kept in a repressed state by intramolecular interactions involving the SH3 and SH2 domains of the enzymes. Ligands for these domains can displace the intramolecular associations and activate the kinases. Here, we carried out in vitro activation experiments...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2045694/ https://ncbi.nlm.nih.gov/pubmed/17719722 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2007.07.012 |
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