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The Evolutionarily Conserved Arrangement of Domains in Src Family Kinases Is Important for Substrate Recognition
The SH3–SH2–kinase domain arrangement in nonreceptor tyrosine kinases has been conserved throughout evolution. For Src family kinases, the relative positions of the domains are important for enzyme regulation; they permit the assembly of Src kinases into autoinhibited conformations. The SH3 and SH2...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2841526/ https://ncbi.nlm.nih.gov/pubmed/18803405 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800930e |
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