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Reengineering the Signaling Properties of a Src Family Kinase
Src family kinases (SFKs) are modular signaling proteins possessing SH3, SH2, and tyrosine kinase domains. The SH3 and SH2 domains of SFKs have dual roles: they regulate the activity of the kinases, and they also target SFKs to their cellular substrates. We generated a series of novel SFKs by replac...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2847435/ https://ncbi.nlm.nih.gov/pubmed/19827767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900978f |
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