Role of the γ-phosphate of ATP in triggering protein folding by GroEL–GroES: function, structure and energetics

Productive cis folding by the chaperonin GroEL is triggered by the binding of ATP but not ADP, along with cochaperonin GroES, to the same ring as non-native polypeptide, ejecting polypeptide into an encapsulated hydrophilic chamber. We examined the specific contribution of the γ-phosphate of ATP to...

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Главные авторы: Chaudhry, Charu, Farr, George W., Todd, Matthew J., Rye, Hays S., Brunger, Axel T., Adams, Paul D., Horwich, Arthur L., Sigler, Paul B.
Формат: Artigo
Язык:Inglês
Опубликовано: Oxford University Press 2003
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Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC204461/
https://ncbi.nlm.nih.gov/pubmed/14517228
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/cdg477
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