Intracellular Pharmacokinetics of Once versus Twice Daily Zidovudine and Lamivudine in Adolescents

Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity. The aims of this study were to compare ZDV-TP and 3TC-TP concentrations in adolescents receiving twice daily (BID) and once daily (QD) regimens and to determine the metabolite concentrations o...

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Bibliografiska uppgifter
Huvudupphovsmän: Flynn, Patricia M., Rodman, John, Lindsey, Jane C., Robbins, Brian, Capparelli, Edmund, Knapp, Katherine M., Rodriguez, Jose F., McNamara, James, Serchuck, Leslie, Heckman, Barbara, Martinez, Jaime
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2007
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043291/
https://ncbi.nlm.nih.gov/pubmed/17664328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01626-06
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