Intracellular Pharmacokinetics of Once versus Twice Daily Zidovudine and Lamivudine in Adolescents

Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity. The aims of this study were to compare ZDV-TP and 3TC-TP concentrations in adolescents receiving twice daily (BID) and once daily (QD) regimens and to determine the metabolite concentrations o...

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Détails bibliographiques
Auteurs principaux: Flynn, Patricia M., Rodman, John, Lindsey, Jane C., Robbins, Brian, Capparelli, Edmund, Knapp, Katherine M., Rodriguez, Jose F., McNamara, James, Serchuck, Leslie, Heckman, Barbara, Martinez, Jaime
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2007
Sujets:
Antiviral Agents
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043291/
https://ncbi.nlm.nih.gov/pubmed/17664328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01626-06
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