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Intracellular Pharmacokinetics of Once versus Twice Daily Zidovudine and Lamivudine in Adolescents

Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity. The aims of this study were to compare ZDV-TP and 3TC-TP concentrations in adolescents receiving twice daily (BID) and once daily (QD) regimens and to determine the metabolite concentrations o...

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Main Authors: Flynn, Patricia M., Rodman, John, Lindsey, Jane C., Robbins, Brian, Capparelli, Edmund, Knapp, Katherine M., Rodriguez, Jose F., McNamara, James, Serchuck, Leslie, Heckman, Barbara, Martinez, Jaime
格式: Artigo
語言:Inglês
出版: American Society for Microbiology 2007
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043291/
https://ncbi.nlm.nih.gov/pubmed/17664328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01626-06
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