Intracellular Pharmacokinetics of Once versus Twice Daily Zidovudine and Lamivudine in Adolescents

Zidovudine (ZDV) and lamivudine (3TC) metabolism to triphosphates (TP) is necessary for antiviral activity. The aims of this study were to compare ZDV-TP and 3TC-TP concentrations in adolescents receiving twice daily (BID) and once daily (QD) regimens and to determine the metabolite concentrations o...

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Detalhes bibliográficos
Main Authors: Flynn, Patricia M., Rodman, John, Lindsey, Jane C., Robbins, Brian, Capparelli, Edmund, Knapp, Katherine M., Rodriguez, Jose F., McNamara, James, Serchuck, Leslie, Heckman, Barbara, Martinez, Jaime
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043291/
https://ncbi.nlm.nih.gov/pubmed/17664328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01626-06
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