In Vitro Suppression of K65R Reverse Transcriptase-Mediated Tenofovir- and Adefovir-5′-Diphosphate Resistance Conferred by the Boranophosphonate Derivatives

9-[2-(Boranophosphonomethoxy)ethyl]adenine diphosphate (BH(3)-PMEApp) and (R)-9-[2-(boranophosphonomethoxy)propyl]adenine diphosphate (BH(3)-PMPApp), described here, represent the first nucleoside phosphonates modified on their α-phosphates that act as efficient substrates for the human immunodefici...

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Bibliografiska uppgifter
Huvudupphovsmän: Frangeul, Antoine, Barral, Karine, Alvarez, Karine, Canard, Bruno
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2007
Ämnen:
Antiviral Agents
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2043169/
https://ncbi.nlm.nih.gov/pubmed/17620380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00145-07
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