Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation

Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becomes attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). We have determined three crystal structures of the Methanosarcina mazei PylRS complexed with either AMP–PNP, Pyl–AMP plus pyrophosphate, or the P...

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Autori principali: Kavran, Jennifer M., Gundllapalli, Sarath, O'Donoghue, Patrick, Englert, Markus, Söll, Dieter, Steitz, Thomas A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2007
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040888/
https://ncbi.nlm.nih.gov/pubmed/17592110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0704769104
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