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Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis

SUMOylation of transcription factors often attenuates transcription activity. This regulation of protein activity allows more diversity in the control of gene expression. Interferon regulatory factor-1 (IRF-1) was originally identified as a regulator of IFN-α/β, and its expression is induced by vira...

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Main Authors: Park, Junsoo, Kim, Kwangsoo, Lee, Eun-Ju, Seo, Yun-Jee, Lim, Si-Nae, Park, Kyoungsook, Rho, Seung Bae, Lee, Seung-Hoon, Lee, Je-Ho
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2007
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040422/
https://ncbi.nlm.nih.gov/pubmed/17942705
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609852104
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