sMEK1 inhibits endothelial cell proliferation by attenuating VEGFR-2-dependent-Akt/eNOS/HIF-1α signaling pathways

The suppressor of MEK null (sMEK1) protein possesses pro-apoptotic activities. In the current study, we reveal that sMEK1 functions as a novel anti-angiogenic factor by suppressing vascular endothelial growth factor (VEGF)-induced cell proliferation, migration, and capillary-like tubular structure i...

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Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Kim, Boh-Ram, Seo, Seung Hee, Park, Mi Sun, Lee, Seung-Hoon, Kwon, Youngjoo, Rho, Seung Bae
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2015
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4741643/
https://ncbi.nlm.nih.gov/pubmed/26378810
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