The anti-tumor activator sMEK1 and paclitaxel additively decrease expression of HIF-1α and VEGF via mTORC1-S6K/4E-BP-dependent signaling pathways

Recently, we found that sMEK1 effectively regulates pro-apoptotic activity when combined with a traditional chemotherapeutic drug. Therefore, combinational therapeutic strategies targeting critical molecular and cellular mechanisms are urgently required. In this present work, we evaluated whether sM...

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Detalhes bibliográficos
Main Authors: Kim, Boh-Ram, Yoon, Kyungsil, Byun, Hyun-Jung, Seo, Seung Hee, Lee, Seung-Hoon, Rho, Seung Bae
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4171649/
https://ncbi.nlm.nih.gov/pubmed/25153728
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