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Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis
SUMOylation of transcription factors often attenuates transcription activity. This regulation of protein activity allows more diversity in the control of gene expression. Interferon regulatory factor-1 (IRF-1) was originally identified as a regulator of IFN-α/β, and its expression is induced by vira...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040422/ https://ncbi.nlm.nih.gov/pubmed/17942705 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0609852104 |
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