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Processing and Trafficking of a Prohormone Convertase 2 Active Site Mutant
Processing of most PC zymogens is required for successful folding and/or passage through the secretory pathway; active site mutants are retained in the ER and degraded. We here report that the active site serine mutant of PC2 (PC2-S383A) was efficiently secreted as the intact zymogen in CHO-K1 cells...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2007
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2040296/ https://ncbi.nlm.nih.gov/pubmed/17320043 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.02.034 |
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