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Processing and Trafficking of a Prohormone Convertase 2 Active Site Mutant

Processing of most PC zymogens is required for successful folding and/or passage through the secretory pathway; active site mutants are retained in the ER and degraded. We here report that the active site serine mutant of PC2 (PC2-S383A) was efficiently secreted as the intact zymogen in CHO-K1 cells...

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Detalhes bibliográficos
Main Authors: Lee, Sang-Nam, Kacprzak, Magdalena M., Day, Robert, Lindberg, Iris
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2040296/
https://ncbi.nlm.nih.gov/pubmed/17320043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2007.02.034
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