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Modulation of Prohormone Convertase 1/3 Properties Using Site-Directed Mutagenesis
Prohormone convertase (PC)1/3 and PC2 cleave active peptide hormones and neuropeptides from precursor proteins. Compared with PC2, recombinant PC1/3 exhibits a very low specific activity against both small fluorogenic peptides and recombinant precursors, even though the catalytic domains in mouse PC...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Endocrine Society
2010
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2940488/ https://ncbi.nlm.nih.gov/pubmed/20610561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2010-0296 |
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