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Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification
Rad18 is a ubiquitin E3 ligase that monoubiquitinates PCNA on stalled replications forks. This allows recruitment of damage-tolerant polymerases for damage bypass and DNA repair. In this activity, the Rad18 protein has to interact with Rad6, the E2 ubiquitin-conjugating enzyme, ubiquitin, PCNA and D...
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| Main Authors: | , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Oxford University Press
2007
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2034485/ https://ncbi.nlm.nih.gov/pubmed/17720710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm615 |
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