Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

Rad18 is a ubiquitin E3 ligase that monoubiquitinates PCNA on stalled replications forks. This allows recruitment of damage-tolerant polymerases for damage bypass and DNA repair. In this activity, the Rad18 protein has to interact with Rad6, the E2 ubiquitin-conjugating enzyme, ubiquitin, PCNA and D...

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Bibliographic Details
Main Authors: Notenboom, Valerie, Hibbert, Richard G., van Rossum-Fikkert, Sarah E., Olsen, Jesper V., Mann, Matthias, Sixma, Titia K.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2007
Subjects:
Nucleic Acid Enzymes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2034485/
https://ncbi.nlm.nih.gov/pubmed/17720710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkm615
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