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Rolling and transient tethering of leukocytes on antibodies reveal specializations of selectins

Antibodies immobilized on the wall of a flow chamber can support leukocyte rolling in shear flow. IgM mAb to Lewis(x) (CD15) and sialyl Lewis(x) (CD15s), which are carbohydrate antigens related to selectin ligands, plus mAb to CD48 and CD59, could mediate rolling. IgM and IgG mAb to L-selectin (CD62...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Chen, Shuqi, Alon, Ronen, Fuhlbrigge, Robert C., Springer, Timothy A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC20341/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9096365/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.7.3172
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