Squalene-derived Flexible Linkers for Bioactive Peptides

A regiochemical and stereochemical mixture of flexible linkers bearing terminal azide functionality was synthesized in two steps from squalene and was used to connect two high affinity NDP-α-MSH ligands or two low affinity MSH(4) ligands. The ligands were N-terminally acylated using N-hydroxysuccini...

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Autori principali: Jagadish, Bhumasamudram, Sankaranarayanan, Rajesh, Xu, Liping, Richards, Reyniak, Vagner, Josef, Hruby, Victor J., Gillies, Robert J., Mash*, Eugene A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2033335/
https://ncbi.nlm.nih.gov/pubmed/17448660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2007.04.001
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