Targeted disruption of p70(s6k) defines its role in protein synthesis and rapamycin sensitivity

Here, we disrupted the p70 S6 kinase (p70(s6k)) gene in murine embryonic stem cells to determine the role of this kinase in cell growth, protein synthesis, and rapamycin sensitivity. p70(s6k−/−) cells proliferated at a slower rate than parental cells, suggesting that p70(s6k) has a positive influenc...

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Main Authors: Kawasome, Hideki, Papst, Philip, Webb, Saiphone, Keller, Gordon M., Johnson, Gary L., Gelfand, Erwin W., Terada, Naohiro
Formato: Artigo
Idioma:Inglês
Publicado: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC20208/
https://ncbi.nlm.nih.gov/pubmed/9560223
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